AMIODARONE

Mechanism of action

Prolongs APD: attributable to block of myocardial K+ channels. Preferentially blocks inactivated Na+ channels (like Lignocaine) with relatively rapid rate of channel recovery. Inhibits myocardial Ca2+ channels and has noncompetitive b adrenergic blocking property. Amiodarone is slowly and poorly absorbed after oral administration. It accumulates in fat and muscle and is metabolized slowly in liver. One metabolite is active. Action starts in 2-3 days when given orally. On I.V action starts in 1-5 min. t½ is 3-8 weeks

 

Indications

Ventricular tachycardia, ventricular fibrillation, tachyarrhythmia’s associated with WPW syndrome, atrial flutter and fibrillation specially in cases refractory to other treatments

 

Dosage

Adults: Oral : 400-600 mg/day for few weeks, followed by 100-200 mg once a day for maintenance therapy

Inj : Rarely used, 5mg/kg slow I.V. injection over 30-60 min

 

Children: Not recommended

 

Contraindications

Avoid in patients with Cardiogenic shock, severe bradycardia, lung diseases, myasthenia gravis

 

Special Precautions

Caution in patients with hepatic, renal and cardiac dysfunction. Lowest tolerable dose usually less than 200mg per day, once a day should be used as maintenance therapy

 

Adverse Drug Reactions

Fall in BP and myocardial depression occurs on i.v. injection. Nausea, gastrointestinal upset are common. Long term use leads to photosensitization, skin pigmentation occurs in about 10% patients and rarely it causes corneal micro deposits. Pulmonary alveolitis and fibrosis is the most serious toxicity of prolonged use. Other side effects include peripheral neuropathy, liver damage, hypo or hyper thyroidism

 

Status in

1. Pregnancy    : Contraindicated

2. Lactation      : Contraindicated

3. Old age        : Use with caution

4. Children       : Contraindicated

 

Interactions

Digitalis glycosides: Reduced renal digoxin excretion leads to increased plasma digoxin concentrations; Warfarin : Metabolism of Warfarin is inhibited and hypoprothrombinemic effect is augmented; Theophylline : Levels of theophylline may increase; Rifampicin, Phenytoin : May decrease levels of amiodarone; Procainamide, Quinidine : May increase their levels

 

 

Brands available and preparations of AMIODARONE

 

Pharmaceutical Company

Brand Name

Sain Medicaments

ADIPIN                         

§ 10 Tab                 2.5mg

§                               5mg 

§                             10mg

 

Caplet India

ADP                             

§ 10 Cap                 2.5mg

§                               5mg 

§                             10mg

 

Orchid

AM-5                                 

§ 10 Tab                    5mg  

Ajanta

AMADAY                           

§ 10 Tab                 2.5mg

§                               5mg

§                             10mg

 

Solares

AMANAT                        

§ 10 Tab                    5mg

§                              10mg

 

Systopic

AMCARD                       

§ 10 Tab                 2.5mg 

§                               5mg

§                             10mg 

 

Indoco

AMCHEK                           

§ 10 Tab                 2.5mg

§                               5mg

§                             10mg

 

IRM    Pharma

AMDEPIN              

§ 10 Tab                 2.5mg 

§                               5mg

§                             10mg 

 

Dallas Pharma

AMDIP                         

§ 10 Tab                    5mg 

 

Novartis

AMLIBON                       

§ 10 Tab                 2.5mg 

§                               5mg 

 

Cadex

AMLICA                            

§ 10 Tab                  2.5mg

§                                5mg 

§                              10mg 

 

Candor Biotech

AMLOCAIN                 

§ 10 Tab                    5mg 

 

Globus

AMLOC                            

§ 10 Tab                    5mg 

§                             10mg

 

Comed

AMLOCOM                     

§ 10 Tab                    5mg

§                              10mg

 

Torrent

AMLOCOR                      

§ 10 Tab                 2.5mg 

§                               5mg  

§                             10mg 

 

Zydus Cadila

AMLODAC                  

§ 10 Tab                  2.5mg 

§                                5mg

§                              10mg

 

Life Medicare

AMLOKATH                

§ 10 Tab                    5mg

 

Mankind  Pharma

AMLOKIND                  

§ 10 Tab                 2.5mg

§                               5mg

 

Raptakos

AMLOKOS                   

§ 10 Tab                 2.5mg 

§                               5mg

§                             10mg

 

Pfizer

AMLOGARD                       

§ 10 Tab                    5mg

§                              10mg

 

Bergen (Alkem)

AMLOGEN                   

§ 7 Tab                      5mg

§                              10mg

 

Kansas Lab

AMLOKAN-5               

§ 10 Tab                    5mg

 

Themis Medicare

AMLOL                       

§ 10 Tab                    5mg

 

Carsyon

AMLONG                       

§ 10 Tab                 2.5mg

§                               5mg

§                            7.5mg

§                             10mg

 

Cipla

AMLOPRES                         

§ 10 Tab                  2.5mg

§                                5mg

§                              10mg

 

Genetica

AMLOSAFE                  

§ 10 Tab                  2.5mg

§                                5mg

§                              10mg

 

Biochem

AMLOSTAT                  

§ 10 Tab                    5mg

 

Nicholas

AMLOSYL                     

§ 10 Tab                  2.5mg

§                                5mg

§                              10mg

 

Sun

AMLOSUN                             

§ 10 Tab                   2.5mg 

§                                 5mg 

§                               10mg

 

Zota Pharma

AMLOZED                   

§ 10 Tab                    5mg 

 

Varun Life sciences

AMNORM                    

§ 10 Tab                  2.5mg

§                                5mg

§                              10mg

 

USV

AMLOPIN                              

§ 10 Tab                  2.5mg

§                                5mg

§                              10mg

 

Biochem

AMLOSTAT -5             

§ 10 Tab                    5mg

 

Sun  Pharma

AMLOSUN                   

§ 10 Tab                  2.5mg

§                                5mg

§                              10mg

 

SPPL (Speciality Div)

AMLOSYL                   

§ 10 Tab                  2.5mg

§                                5mg

§                              10mg

 

Intra Labs

AMLOTRAC-5

§ 10 Tab                    5mg

 

Macleods

AMLOVAS                  

§ 10 Tab                 2.5mg

§                               5mg

§                             10mg

Plethico

AMLOZ                          

§ 10 Tab                  2.5mg

§                                5mg

§                              10mg

 

FDC

AMODEP                                

§ 10 Tab                    5mg

§                             10mg

 

Sunij Pharma

AMPINE                       

§ 10 Tab                 2.5mg

§                               5mg 

Riasma Life science

AMOM                         

§ 10x10 Tab              5mg

 

Finecure

AMOPIN                        

§ 10 Tab                    5mg

 

Rapross

AMPINE                         

§ 10 Tab                    5mg

 

Intas

AMTAS                                

§ 10 Tab                  2.5mg

§                                5mg

§                              10mg

 

Croslands

AMPREZ                      

§ 6 Tab                       5mg

§                               10mg

 

Sarabhai Chemical

AMSACH                     

§ 10 Tab                  2.5mg

§                                5mg

§                              10mg

 

Synmedic Lab

AMSYN                        

§ 10x10 Tab               5mg

 

Zee Lab

AMZEL-5                        

§ 20 Tab                    5mg

 

Blue Cross

ANGICAM                   

§ 10 Tab                  2.5mg

§                                5mg

 

Ind-Swift

ANGIGUARD                

§ 10 Tab                    5mg

 

GR Labs

APIN                               

§ 10 Tab                    5mg

 

Genesis Biotec

ATEMOS                     

§ 10x10 Tab               5mg

 

EWF Pharma

BP-MADE                    

§ 10 Tab                    5mg

§                             10mg

 

IPCA

CALCHEK                             

§ 10 Tab                  2.5mg

§                                5mg

§                              10mg

 

Kapeetus Medicorp

CALOCK                     

§ 10x10 Tab              5mg 

 

Biogenetic

CARDIPIN                    

§ 10 Tab                    5mg

 

Ultramark H.Care

CARDPIN                     

§ 10 Tab                    5mg

 

East African (R)

CARDRIV                     

§ 10 Tab                    5mg

 

Argus

CARVASC                         

§ 10 Tab                    5mg

§                             10mg

 

Unisearch

CORVADIL                  

§ 10 Tab                 2.5mg

§                               5mg

§                             10mg

 

elegant drugs

CONSOLE-ED

§ 10 Tab                    5mg

§                             10mg

 

Unisearch

CORVADIL      

§ 10 Tab                  2.5mg 

§                                5mg        

§                              10mg        

 

Biological E

DIAVASC                    

§ 10 Tab                    5mg        

 

Alkem

DIP 

§ 10 Tab                 2.5mg

§                               5mg        

§                             10mg        

 

Signit Lab

DENCARD  (Amlodipine as besylate)

§ 10x10 Tab           2.5mg           

§                              5mg           

§                            10mg           

 

E.Merck

EMADINE                        

§ 10 Tab                 2.5mg        

§                               5mg        

 

Elfin Pharma

EMIDINE (Amlodipine as besylate)

§ 10 Tab                 2.5mg

§                               5mg 

§                             10mg  

 

Excare Lab

EXLODEP   (Amlodipine 5mg)

§ 20 Tab    

 

Kopran

KLODIP                            

§ 10 Tab                 2.5mg        

§                               5mg        

§                             10mg        

 

Stadmed

LAMA                           

§ 10 Tab                 2.5mg        

§                               5mg        

§                             10mg        

 

Phytochem

LEODIP (Amlodipine)

§ 10 Tab                    5mg           

§                             10mg           

 

Wockhardt

MYODURA                   

§ 7 Tab                   2.5mg        

§                               5mg        

§                             10mg        

 

Aldemedi Impex

NIPIDOL                       

§ 10 Tab                 2.5mg          

§                               5mg        

 

Emcure

NUMLO                           

§ 10 Tab                 2.5mg          

§                               5mg        

§                             10mg        

Biocin H.Care

ODIPIN                   

§ 10 Tab                 2.5mg          

§                               5mg          

§                             10mg        

 

Pharma Drugs & Chemicals

PDPINE                        

§ 10x5x10                 5mg      

 

Medley

PRIMODIL                        

§ 10 Tab                 2.5mg          

§                               5mg          

§                             10mg        

 

Dr.  Redy’s Lab

STAMLO 

§ 10 Tab                 2.5mg        

§                               5mg        

§                             10mg        

 

Merind

TAMLOD                          

§ 10 Tab                    5mg        

§                             10mg      

 

Rpg Life Sciences

TOPDIP                        

§ 10 Tab                 2.5mg          

§                               5mg        

§                             10mg        

 

Stancare

VAMLO                         

§ 10 Tab                 2.5mg

§                               5mg                                    

§                             10mg