DOMPERIDONE

 

Mechanism of Action

It is a D2 antagonist, chemically related to haloperidol, but pharmacologically related to metoclopramide. The central anti-dopaminergic action on CTZ is responsible for its antiemetic action. It does not cross blood brain barrier. Accordingly, extra pyramidal side effects are rare, antiemetic efficacy is lower than metoclopramide. Cholinergic action in GIT helps to increase lower esophageal sphincter tone and promotes gastric emptying. It is well absorbed orally but only 15% is bioavailability. Plasma t is 7.5 hrs.

 

Indications

All types of nausea and vomiting secondary to any disease or drug and in post-operative period

It is less effective in chemotherapy or radiotherapy induced vomiting

 

Dosage  

Adults:  1-2 tabs 8 hourly

 

Children: Oral: 1-2mg/kg/dose 6-8 hourly

I.V.: 0.1-0.2mg/kg/dose

 

Contraindication

Patients with gastrointestinal hemorrhage and obstruction

 

Special Precaution

I.V. injection can lead to cardiac arrhythmias

 

Caution in patients with severe liver and renal impairment

 

Adverse Drug Reactions

Dry mouth, loose stools, galactorrhoea, skin rash

 

Status in

1. Pregnancy: Contraindicated

2. Lactation  : Use with caution

3. Old age    : Use with caution

4. Children   : May be used

 

 

 

Brands available and preparations of DOMPERIDONE

 

Pharmaceutical Company

Brand Name

RPG Pharma

ARKADOM

10 Tab 10mg

Azine H. Care

AZINORM

10 Tab                  10mg

30ml Susp          1mg/ml

 

Cosme HC

COSDOME

10 Tab                    5mg

10mg

 

Intra Labs

DOMACT

10 DT                    10mg

30ml Sus.         1mg/5ml

 

Zydus Cadila

DOMCOLIC

50X10 Tab            10mg

30ml Syrup         1mg/ml

Medipol Pharma

DOMDON

30ml Syrup       5mg/5ml

Intas

DOMEL-MT

10 Tab                  10mg

National C. & Pharma

DOMET

30ml Drops             1mg

 

DOMITIL

Bal Pharma

10 Tab                   10mg

Raptakos

DOMNE-CR

10 Tab CR           30mg        

IPCA

DOMPERI-DT

10 Tab                    5mg

10mg

30ml Sus            1mg/ml 

 

IRM Pharma

DOMPERON

10 Meltab                5mg

10mg

30ml Sus            1mg/ml

5ml Dps            10mg/ml

 

DOMPERON OD

10 Cap                  30mg

 

Finecure Pharma

DOMPON

10 Tab                  10mg

30ml Sus            1mg/ml

Lifeon

DOMESTTLER SUSP.

30ml Sus.           1mg/ml

 

Torrent

DOMSTAL

10 DT/MT                5mg

10 DT/MT/Tab       10mg

10 Tab                  20mg

30ml Sus            1mg/ml

 

DOMSTAL-OD 

10 Tab                  30mg

                 

Atoz Pharma

DOMAT

10 Tab                  10mg

 

Chemo Drugs

DOMPET

10 Tab                  10mg

DOMPIWIN-10 DT

Wintech

10 Tab                  10mg

Adley Lab

DOMPRO

10 Tab                  10mg

Ray Remedies

DOMRAY MD

10 Tab                  10mg

Wens Drugs

 

DOMSTAL-5 DT 

10 Tab                  10mg

30ml Drops         1mg/ml

 

KAPL

EMIDON-DT

10 DT                    10mg

30ml Sus             1mg/ml

Cachet

EMITIN

10 Tab                  10mg

30ml Sus            1mg/ml

Ethnor

GASTRIACTIV

10 Tab                  10mg

30ml Sus            1mg/ml

Micro Nova

GASTRIUM

10 Tab/DT             10mg

30ml Sus             1mg/ml 

Medley

MOTINORM 

10 DT                    10mg

30ml Syr.             1mg/ml 

5ml Dps             10mg/ml  

 

MOTINORM OD

10 Tab10 Tab      10mg

30ml Sus            1mg/ml  

 

Knoll

NAUSIDOME 

10 Tab                  10mg 

30ml Sus             1mg/ml

 

Wallace

PRODOM

10 Tab                  10mg

30ml Sus          5mg/5ml

10ml Dps          10mg/ml

 

Sanat

SAN-DT

10 DT                    10mg

Cadila Pharma

STOPVOM

10 Tab                  10mg

30ml Paed Syr.   1mg/ml

 

Taurus Labs

TARURDOM

10 Tab                  10mg 

30ml Sus            1mg/ml

 

TRIDOM

Zydus  Vaccicare

10 DT                      5mg

30ml Sus            1mg/ml

Mars

EMSTAL-5

10 Tab                    5mg

30ml Susp        1mg/1ml

 

EMSTAL-10

10 Tab                  10mg

 

Themis Pharma

ENDOPACE

10 Tab                  10mg

60ml Susp          1mg/ml

 

Johnson & Johnson  

GASTRACTIV

10 Tab      10mg     

30ml Susp          1mg/ml        

Sigma Lab

MOTIWIN

10 Tab                  10mg         19.50           N.A.

5ml Drops         10mg/ml         22.00           N.A.

30ml Susp          1mg/ml         22.50           N.A.

 

Bestochem

NAUSHI

30ml Drops         1mg/ml  

Mankind

NUDOM

10 Tab                  10mg 

Bupa Pharma

PERIDOM

10 Tab                  10mg

 

Mercury H.care

PERIDON

10 Tab                  10mg

30ml Susp          1mg/ml

5ml Drops           1mg/ml

 

Dynamic

PERIN

10 Tab                  10mg

 

Dallas Pharma

RIO

10 Tab                  10mg

Swede-india

SOLO-DOM

10 Tab                  10mg

10 Tab                  10mg

 

Helios Pharma

 

UGINORM MT

10 Tab                    5mg

10 Tab                  10mg

 

Zota H.care

VARDOM-DT

10 Tab                  10mg

 

Shreeyam H.care

VELRID

10 Tab                    5mg

 

VELRID MD

10 Tab                  10mg

Marc Lab

VOMIDOM

30ml Susp        5mg/5ml

10 Tab                  10mg

 

Olcare Lab

VOMIDON-MD             

10 Tab                    5mg

10 Tab                  10mg

 

VOMIDON  

30ml Susp          1mg/ml

 

Esteem Pharma

VOMIDONE

10 DT                    10mg

10 DT                    20mg

 

Pure Health

VOMSTAL  

10 Tab                  10mg

 

Dagon Pharma

ZINDOM   

25 Tab                  10mg 

 

Kamron Lab.

ZIDON-DT

10 Tab                  10mg

 

Chemo Biological

ZOME   

10 Tab                  10mg

 

ZYDOM-DT

 

Zota Pharma

10 Tab                  10mg

 

ACIGRIP

Valiant H.care (Pantoprazole 40mg, Domperidone 20mg)

10 Cap

Azine H.care

AZINORM MPS (Domperidone 10mg, Simethicone 125mg)

10 Cap

 

Candor Biotech

CANOZOL-D (Pantoprazole 40mg, Domperidone 10mg)

10 Tab

 

Udik Pharma

DOM-M.P.S. (Domperidone 10mg, Methlpolysiloxane 50mg)

10 Tab

Adley Lab

DOMOL-R (Domperidone, 10mg, Ranitidine 150mg)

10 Tab

Medley

DOMPAN (Domperidone, 10mg, Pantoprazole 20mg)

10 Tab

Finecure Pharma

DOMPON-F (Demoperidone 10mg, Famotidine 20mg)

10 Tab

Torrent

DOMSTAL MPS (Domperidone 10mg, Activated dimethicone 125mg)

10 Tab

Rapross

DOMTAC (Pantoprazole 20mg, Domperidone 10mg)

10 Tab

Talson Pharma

DOMTAL-D (Pantoprazole 40mg, Domperidone 5mg)

20 Tab

Medicamen Biotech

FISKER-D (Pantoprazole 20mg, Domperidone 10mg)

10 Tab

Azine H.care

FULPAN-D (Pantoprazole 20mg, Domperidone 10mg)

10 Tab

Phytochem

FYPAN-D (Pantoprazole 30mg, Domperidone 10mg)

10 Tab

Ravenbhel Pharma

ODPANT-DM (Pantoprazole 40mg, Domperidone 10mg)

10 Tab

Zota Pharma

OMEVAR-D (Omeprazole 20mg, Domperidone 10mg)

10 Cap

Astam H. Care

PANCER-D (Pantaprazole 40mg, Domperidone 10mg)

Tab

Galpha Lab

PANDOSTAL (Pantoprazole 40mg, Domperidone 10mg)

10 Cap

Stadchem

PANGARD-PLUS (Pantoprazole 40mg, Domperidone 10mg)

2x50 Tab

Shinto Organics

PANPRA-D (Pantoprazole 40mg, Domperidone 10mg)

10 Tab

Ray Remedies

PANRAY D (Pantoprazole 40mg, Domperidone 10mg)

10 Tab

Novagen Pharma

PANSTROM D (Pantoprazole 20mg, Domperidone 10mg)

10 Tab

Active H.care

PANTACT-D (Pantoprazole 20mg, Domperidone 10mg)

10 Tab

Dallas Pharma

PANTADAL-D (Pantoprazole 20mg, Domperidone 10mg)

10x10 Tab

Mankind

PANTADOM  (Pantoprazole 20mg, Domperidone 10mg)

10 Cap

 

East African(r)

PANTARIV-D (Pantoprazole 20mg, Domperidone 10mg)

10 Tab

Cure Quick

PANTOMAX-D (Pantoprazole 40mg, Domperidone10mg)

10x10 Tab

Euromed Lab

PANTOMED-D  (Pantoprazole 40mg, Domperidone 10mg)

10x10 Tab

Admac Pharma

PANTON-D (Pantoprazole 40mg, Domperidone 10mg)

10 Tab

Aristo Pharma

PANTOP-D (Pantoprazole 20mg, Domperidone 10mg)

10 Cap

Cipla

PANTOSEC-D (Pantoprazole 40mg, Domperidone 10mg)

10 Tab

 

Zee Lab

PANZEL-DM (Pantoprazole 20mg, Domperidone 10mg)

10 Tab

R.K. Pharma

PENTIZOL-D (Pantoprazole 40mg, Domperidone 10mg)

20x10 Tab

Finecure

PEPCARE D (Pantoprazole 40mg, Domperidone 10mg)

10 Tab

Scortis Labs

PROPAN-D (Pantoprazole 40mg, Domperidone 10mg)

10 Tab

 

Lexus (India)

PROPLUS-DM (Pantoprazole 40mg, Domperidone 10mg)

10 Tab

Cubit Healthcare

SENT-D (Pantoprazole 40mg, Domperidone 10mg)

10x10 Tab

Saviour Pharma

SPENT-D (Pantoprazole 20mg, Domperidone10mg)

10 Tab

Systopic

 

SYSPERIDON MPS  (Domperidon 10mg, methyl  polysiloxane 125mg) 

10 Tab                                  

Prochem

TACID-D (Pantoprazole 20mg, Domperidone10mg)

10 Tab

Parex Pharma

THERACID-D (Pantoprazole 40mg, Domperidone 10mg)

10 Tab

Cachet Pharma

TOPDOM (Pantoprazole 20mg, Domperidone 10mg)

10 Cap

 

Espira Life Sciences

TURBODOM P (Pantoprazole 40mg, Domperidone 10mg)

10 Tab

Esteem Pharma

VOMIDONE O (Pantoprazole 20mg, Domperidone 10mg)

10 Cap

 

 

Brands available and combination preparations of DOMPERIDONE and PARACETAMOL

Pharmaceutical Company

Brand Name

Admac Pharma

ADOM-P (Domperidone 10mg, Paracetamol 500mg)

  10 Cap

 

Cubit Healthcare

CUDOM-P (Domperidone, 20mg, Paracetamol 500mg)

  10x10 Tab

Protec

DOMCET

(Domperidone 10mg, Paracetamol 500mg in each tab or per 10ml sus.)

  10 Tab     

  30ml Sus   

 

Shinto Organics

DOMIT-P (Demoperidone, 10mg, Paracetamol 500mg)

  10 Tab

IRM Pharma

DOMPERON PLUS (Domperidone 10mg, Paracetamol 500mg)

  10 Tab

Finecure Pharma

DOMPON P (Domperidone 20mg, Paracetamol 500mg)

  10 Tab

Torrent

DOMSTAL-P (Domperidone 10mg, Paracetamol 500mg)

  10 Tab

Zee Lab

DOSET PLUS (Domperidone 10mg, Paracetamol 500mg)

  20 Tab

KAPL

GRENIL

Tab : (Domperidone 20mg,  paracetamol 500mg)

  10 Tab

Sus : (Domperidone 5mg, paracetamol 250mg, per 5ml)

  50ml Sus.               

 

Medley

MOTINORM-P (Domperidone 10mg, Paracetamol 500mg)

  10 Tab

 

Bestochem

PARADON (Paracetamol 500mg, Domperidone 10mg)

  10 Tab

PYRONA    

Norwest Pharma

(Paracetamol 500mg, Domperidone 20mg)

  10 Tab

(Paracetamol 250mg, Domperidone 5mg/ml)

  60ml Susp