ANTI – HELICOBACTER PYLORI DRUGS

H.pylori is a gram negative bacillus uniquely adapted to survival in the hostile environment of stomach. It attaches to the surface epithelium beneath the mucus, has high urease activity and produces ammonia which maintains a neutral microenvironment around the bacteria and promotes back diffusion of H+ ions and is now accepted as an important contributor to the causation of chronic gastritis, dyspepsia, peptic ulcer, gastric lymphoma and gastric carcinoma

 

Mechanism of Action

Anti H.pylori therapy consists of combination of antimicrobials like amoxycillin or clarthromycin and nitroimadazoles (Metronidazole, Tinidazole and Ornidazole)

 

Eradication of H.pylori concurrently with H2 blocker /PPI therapy of peptic ulcer has been associated with faster ulcer healing and lower relapse rate

 

Indications

Recommended in all patients with peptic ulcer who test positive for H.pylori

 

Also used in recurrent peptic ulcers

 

Dosage

Adults: 1 kit daily for 14 days

Children: Not recommended

 

Contraindications

Known hypersensitivity to any compound

 

Adverse Drug Reactions

 All regimens are complex and expensive and compliance is poor. Nausea, vomiting, loose stools, fatigue, abdominal cramps and headache dizziness

 

Occasionally hypersensitivity reactions like skin rashes and angioedema

 

Status in

1. Pregnancy: Contraindicated

2. Lactation  : Contraindicated

3. Old age     : May be used

4. Children   : Not recommended

 

 

Brands available and Combination Preparations of ANTI – HELICOBACTER PYLORI DRUGS

 

Pharmaceutical Company

Brand Name

Biological E

GI KIT (2 tabs of Clarthromycin 250mg, 2 tabs of Amoxycillin 750mg, 2 caps of Omeprazole 20mg)

§     6 Tab Kit

RPG

HELIBACT (Each kit Contains two Omeprazole 20 mg cap, two Amoxycillin 750mg tab, two Tinidazole 500 mg tab)

§     2 Kit

Intas

HELIGO (One kit contains a combipack of 2 capsules of Lansoprazole 30mg, 2 tab of Clarithromycin 250mg, 2 tab of Tinidazole 500mg)

§     1 Combipack

 

 


 

Zydus Cadila

HELIKIT (One Kit contains 1 tab/cap of Omeprazole 20mg each, 2 tabs of Amoxycillin 750mg each, 2 tabs of Tinidazole 500mg, each)

§     One Kit

Protec

HELIPAC (Each kit contains two Omeprazole 20 mg cap, two Amoxycillin 750 mg tab, two Tinidazole 500 mg tab)

§     One Kit

Sun Pharma

HP KIT (One kit contains 1 tab/cap of Omeprazole 20mg, Amoxycillin 750mg, Tinidazole 500mg each)

§     One Kit

Lupin

L-COT (One Kit contains two strips, each with one tab/cap of Clarithromycin 250mg, Amoxycillin 500mg, Tinidazole 500mg)

§     One Kit

Zydus Alidac

LANSI KIT (One kit contains 1 tab/cap each of Omeprazole 20mg, Amoxycillin 750mg, Tinidazole 500mg)

§     Two Kit

Ind-Swift

LTC-KIT (Each Kit contains 2 cap of Lansoprazole 30mg, 2 tab of Tinidazole 500mg, and 2 tabs of Clarithromycin 250mg)

§     Each Kit

Alkem

OMEPRAZ HP KIT  (One kit contains 1 tab / cap of Omeprazole 20mg, Amoxycillin 750mg, Tinidazole 500mg each)

§     One Kit Pack

Blue Cross

OMEPREN HP KIT (Each kit contains 2 tab of Amoxycillin 750mg each, 2 cap of Omeprazole 20mg, each, 2 tab of Tinidazole 500mg, each)

§     One Kit Pack 

USV

OMOXITIN (One kit contains 1 tab/cap of Omeprazole 20mg, Amoxycillin 750mg, and Tinidazole 500mg each)

§     One Kit Pack

Biochem

OTC-HP KIT (Each kit contains 1 cap of Omeprazole 20mg, 1 tab of Tinidazole 500mg and 1 tab of Clarithromycin 250mg)    

§     Each Kit

Rexter

PYLOBACT KIT (One kit contains 2 tab/cap each of Omeprazole 20mg, Clarithromycin 250mg, Tinidazole 500mg)

§     One Kit Pack

IRM Pharma

PYLOBAN (Each kit contains 2 cap each of Omeprazole 20mg, 2 tablets each of Clarithromycin 250mg, and Tinidazole 500mg each)

§     Each Kit

Cipla

PYLOKT (Each kit contains 2 tabs of Clarithromycin 250mg each, 2 caps of Lansoprazole 30mg, each, 2 tabs of Tinidazole 500mg, each)

§     Each Kit

 

Ranbaxy

PYLOMOX KIT (Each kit contains 2 tabs of Amoxycillin Trihydrate 750mg, each 2 caps of Lansoprazole 15mg each,  2 tabs of Tinidazole 500mg, each)

§     Each strip of 6’s

Knoll

ULCIKIT (Each kit contains 2 caps of Omeprazole 20mg each, 2 tabs of Amoxycillin 750mg, each, 2 tabs of Tinidazole 500mg each)

§     Each kit

 

 

Dr. Reddy’s Lab

ZOVANTA KIT (Each kit contains 2 tab/caps each of Pantoprazole 40mg, amoxycillin 750mg, Tinidazole 500mg)

§     Each Kit of 6”s