DROTAVERINE

 

Mechanism of Action

A novel non-Anticholinergic smooth muscle antispasmodic which acts by inhibiting phosphodiesterase-4 (PDE-4) selective for smooth muscle

 

Elevation of intracellular cAMP/cCMP attends smooth muscle relaxation

 

Indications

Used orally as well as parent rally in intestinal, biliary and renal colics, irritable bowel syndrome, uterine spasms

 

Dosage

Adults: 40-80mg, SOS, 8 hourly

 

Children: 1-6 years: 20mg, SOS, 8 hourly

6-12 years: 40mg, SOS, 8 hourly

 

Contraindications

Known hypersensitivity

Avoid in patients with acute abdomen of unknown etiology or suspected bowel obstruction

 

Adverse Drug Reactions

Headache, dizziness, constipation and flushing

 

Hypotension when given I.V

 

Status in

1. Pregnancy: Use with caution

2. Lactation  : May be used

3. Old age     : May be used

4. Children   :  Use with caution

 

 

Brands available and preparations of DROTAVERINE

 

Pharmaceutical Company

Brand Name

Indoco

CYCLOFAS INJ

     2ml Amp               40mg

DWD Pharma

DETRIM

     2ml Inj.              20mg/ml

 

Tab: (Drotaverine 80mg, Mefenamic Acid 250mg)

     10 Tabs

Intas

DOVERIN

     10 Tabs                  40mg

     80mg

     2ml Amp

Mapra Labs

DROT

     10 Tabs                 40mg

     80mg

     Vial

 


 

Mankind Pharma

DROTIKIND-80

     10 Tabs                  80mg

 

DROTIKIND-M (Drotaverine HCI 80mg, Mefenamic Acid 250mg)

     10 Tabs

NOBEL SPAS (Drotaverine 40mg, Nimesulide 100mg)

     10 Tabs

Walter Bushnell

DROTIN

     10 Tabs                  40mg

 

DROTIN-DS

     10 Tabs                  80mg

     2ml Amp           20mg/ml

 

DROTIN-M (Drotaverine HCI 80mg, Mefenamic acid 250mg)

     8 Tabs

 

DROTIN PLUS (Drotaverine HCI 80mg, Paracetamol 500mg)

     8 Tabs`

Taurus Labs

DROVET

     10 Tabs                  40mg

     80mg

     2ml Amp.          20mg/ml