LIGNOCAINE (LIDOCANINE)

It is a versatile local Anaesthetic, good both for surface application as well as injection and is available in a variety of forms

 

Mechanism of Action

It is an amide linked local Anaesthetic agent. It is well absorbed after parentral administration; it is dealkylated in liver and 75% excreted in urine.

 

Injected around a nerve it blocks conduction within 3 min, whereas procaine may take 15 min.

 

The duration of block with adrenaline is prolonged up to 1.5 hours; also anaesthesia is more intense and longer lasting

 

Indication

Topical anaesthesia in patients with painful hemorrhoids and fissure, minor burns

 

Used for infiltration, nerve block, epidural, spinal and intravenous regional block anaesthesia

 

Used in ointment or jelly form for local application in rectal, vaginal and otological examinations and urethral catheterization

 

Topical spray used in cystoscopy, bronchoscopy and ENT surgeries. Topical eye drops in eye surgeries

 

Dosage

Adult: Surface application: 2% jelly or 5% ointment

Topical application 4% solution.max.200mg

Local infiltration: 1-2% solution with or without adrenaline as required, 3mg per kg max. 500mg

Spinal anaesthesia: 5% heavy solution.1-2ml every 60-90min, usually 25-100mg max. Safe Dose 500mg

 

Children: Dose depends on age, weight, height, clinical condition and site of inj

 

Contraindications

Known hypersensitivity, Patients with AV Block and conduction disturbances

 

Special Precautions

Caution in patients with hepatic and renal dysfunction

 

Resuscitation facilities should be available when local anaesthesia is being given

 

Adverse Drug Reactions

Drowsiness, tinnitus, dysgeusia, dizziness and twitching specially with increasing doses

 

Cardiovascular collapse and cardiac arrest

 

CNS excitation like tremor, nervousness, convulsion

 

At very high toxic doses there is coma and respiratory arrest

 

Rarely anaphylaxis

 

Status in

1. Pregnancy: May be used

2. Lactation  : Use with caution

3. Old age     : May be used

4. Children   : Use with caution

 

Interactions

Propranolol : Decreases clearance of Lignocaine

 


 

Brands available and preparations of LIGNOCAINE

 

Pharmaceutical Company

Brand Name

Indus

APRICAINE                         

   3ml Inj            21.3mg/ml

APRICAINE ADRENALINE (Lignocaine Hcl 21.3mg, Adrenaline 5mcg/ml)

   30ml Inj

Ravian H. Care

CAN (Lidocaine Hydrochloride 2%, Adrenaline 1:80000)

   30ml Inj

Emson Medichem

EMCAINE JELLY (Lignocaine HCl 2% w/w)

   30gm Jelly

SPPL (Speciality Div.)

GESICAINE         

   30ml Vial                  1%

   30ml Vial                2%

GESICAIN 2% VISCOUS

   100ml                       2%

GESICAINE 5% HEAVY (Ligocaine hcl. 53.33mg, Dextrose 75mg, Sodium Hydroxide to adjust pH between 6.3-6.7)

   25x2ml Amp

GESICAINE JELLY (Lignocaine hcl. 2% carbodymethylcellulose 3.5%)

   30ml jelly

GESICAINE OINT.

   10g Oint                   5%

GESICAINE

   30ml                         4%

GESICAINE with ADRENALINE (Lignocaine hcl 2% with 1:80000 adrenaline)

   30ml Vial                 2%

Cadila Pharma

LIGNOCAINE               

   30ml Vial                  2%

Haffkine

LIGNOCAINE                  

   30ml Vial                  1%

ICI

 

LIGNOCAINE with ADRENALINE

   30ml Vial                  2%

Warren

LIGNOX 2% with ADRENALINE

   30ml 

LIGNOX GEL

   30g Gel                    2%

LIGNOX OINT.

   35g Oint                   5%

LIGNOX SPRAY

   100ml 

LIGNOX TOPICAL

   10ml Vial                  2%

   30g Oint                   5%

 


 

Pharmaceutical Company

Brand Name

Neon Labs

LOX 2% with ADRENALINE

(Ligocaine HCL 21.3mg, adrenaline 0.005mg, sod. chloride 6mg, sod. meta-bisulphate 1mg/ml)

   30ML Vial

LOX HEAVY (Ligocaine HCl 53.3mg, dextrose 75mg, per ml)

   10x2ml Amp             5%

LOX JELLY (Ligocaine HCl 2%)

   30g jelly                   2%

LOX 4% TOPICAL (Ligocaine HCL 42.7mg, methyl paraben 1mg, per ml)

   30ml Vial

PRILOX (Lidocaine 25mg, Prilocaine 25mg in each g)

   5g

   30g

Magnus Biotech

MAGCAINE 

(Each ml contains Lignocaine HCl 21.3mg, Adrenaline 0.005mg, Sodium Chloride 6.0mg, Sodium metabisulphite 0.5mg, Methyl paraben 1.0mg)

   30ml Inj

Micro vision

PRIMLA (Lidocaine 2.5% prilocaine 2.5%)

   5g

Claris Life Sciences

SENSINIL          

   2ml Amp                   2%

   5ml Amp                   2%

   30ml Vial                  1%

   30ml Vial                  2%

AstraZeneca

XYLOCAINE                

   30ml Vial                  1% 

   30ml Vial                  2%

   5x2ml Amp               2%

   5x5ml Amp               2%

   5x10ml Amp             2%

XYLOCAINE 5% HEAVY (Lignocaine hcl. 53.3mg, dextrose 75mg, per ml)

   25x2ml Inj

   5x2ml Inj

XYLOCAINE JELLY    

   30g jelly                   2% 

XYLOCAINE OINTMENT

   20g Oint                   5%

   35g Oint                   5%

XYLOCAINE SPRAY (Ligocaine 100mg, ethenol 28.29% v/v, per ml)

   80ml Pump spray

XYLOCAINE TOPICAL

   30ml Vial                  4%

XYLOCAINE VICOOUS

   100ml                       2%

XYLOCAINE with ADRENALINE 2% (Lignocaine hcl 20mg, adrenaline 5mcg, per ml)

   30ml Inj

 

 


 

D.P.P.L

XYLO (Lignocaine HCl 2%)

   30ml Inj

XYLO-ADRENE (Lignocaine HCl with Adrenaline)

   30ml Inj

XYLO-SPINE (Lignocaine HCl with Dextrose)

   2ml Inj

XYLO (Lignocaine HCl 5%)

   20gm Oint