ALFACALCIDOL

 

Mechanism of Action

It is 1a-hydroxycholecalciferol; it is the synthetic derivative of vitamin D3

 

It is a prodrug that is rapidly hydroxylated in the liver to active calcitriol

 

Mechanism of action is similar to vitamin D and it is useful in renal bone diseases

 

Indications

Renal osteodystrophy, Vitamin D resistant rickets and Vitamin D dependant rickets, hypoparathyroidism and osteoporosis

 

Dosage

Adults: 1-2mcg per day

 

Children: 0.05mcg per day

 

Contraindications

Hypercalcemia

 

Special Precautions

Watch for hypercalcemia

 

Adverse Drug Reactions

Hypercalcaemia and Hypophosphatemia

 

Status in

1. Pregnancy: Not applicable

2. Lactation  : Not applicable

3. Old age     : May be used

4. Children    : May be used

 

Interactions

Thiazides: Enhances risk of hypercalcemia

 

 

Brands available and preparations of ALFACALCIDOL

 

Pharmaceutical Company

Brand Name

IRM Pharma

CALCIROL

        10 Cap             0.25mcg

 

CALCIROL PLUS (Alfacalcidol 0.25mcg, Elemental calcium 200mg)

        10 Cap

Prochem

CET (Alfacalcidol 0.25mg Elemental Calcium 500mg)

        10 Tab

Helios Pharma

ACAL (Elemental Calcium 200mg, Alfacalcidol 0.25mcg)

        10 Cap

Medley

ALCIDOL (Alphacalcidol 0.25mcg, calcium carbonate 500mg)

        10 Soft gel Cap

Raptakos

ALFA CALCINOL (Alfacalcidol 0.25mcg, Calcium carbonate 0.593g, Calcium citrate 59.6mg, Tribasic calcium phosphate 40mg, Magnesium hydroxide 50mg)

        3 x 10 Tab

Marks Remedies

ALFA CAPS

        10 Cap             0.25mcg

 

ALFA CAPS PLUS

        10 Cap             0.25mcg

 

(Alfacalcidol 0.25mcg, Calcium carbonate 1000mg, Calcium citrate 1000mg, Elemental zinc 7.5 mg)

        10 Soft gel Cap

Mankind

ALFA MAXICAL-500

(Alfacalcidol 0.25mcg, Calcium carbonate 1250mg, equiv. to Elemental calcium 500mg)

        15 Soft gel Cap

Otsira Genetica

ALFA OSTEBON

(Altacalcidol 0.2mcg, Elemental Calcium 200mg, derived from cal carbonate from organic sources (oyster shell)

        10 Caps

Bantom Lab

ALFABAN

        10x10 Cap       0.25mcg

 

ALFABAN CA

(Alphacalcidol 0.25mcg, Calcium Carbonate 375mg, Beta-Carotene 2500 I.U.Soft Gel Capsules)

        10x10 Cap

Mdc Pharma

ALFABON

(Alphacalcidol 0.25mcg, Calcium Carbonate (oyster shell) equiv. to Elemental Calcium 200mg)

        10 Tab

Modi-Mundi

ALFABON D

        10 Cap             0.25mcg

Macleods

ALFACAL

        10 Soft gel Cap 0.25mcg

        1mcg

Instant Remedies

ALFACAL

(Alphacalcidol 0.2smcg, Calcium Carbonate 200mg)

        10 Cap

Mark Remedies

ALFACAPS PLUS

        10 Tab

Cure Quick Pharma

ALFACARE

(Alfacalcidol O.2mcg, Elemental Calcium 200mg)

        10 Tab

Cipla

ALFACIP PLUS                   

(Alfacalcidol 0.25mcg, 625mg calcium carbonate from organic source (oyster shell) equiv. to elemental calcium 250mg)

        10 Cap            626mcg

 

(Alfacalcidol 0.25mcg, 1.25g calcium carbonate from organic source (oyster shell) equiv. to elemental calcium 500mg)

        10 Cap            1.25g

Stadchem

ALFAMIX 

(Alphacalcidol 0.25mcg, Organic Calcium 500mg)

        6x10 Cap

Indo-French MC

ALFAFLAVON

(Alfacalcidol 0.25mcg, calcium citrate 425mg, calcium panthothenate 12.5mg, isoflavonoid(40%) 30mg, Vit. E acetate 10i.u. betacarotene 5.17mg, vit. B1 5mg vit. B2 5mg, vit. B2 vit. B12  7.5mcg, selenium (dioxide) 82.5mcg, zinc (oxide)15 mg, folic acid 500mcg, copper 1mg, maganese 1mg, magnesium (oxide)40mg)

        10 Soft gel Cap

GSK

ALPHA D3

        10 Cap             0.25mcg

        1mcg

Panacea

ALPHADOL

        10 Cap            0.25mcg

        1mcg

 

ALPHADOL-C

(Alpha calcidol 0.25mcg, calcium carbonate (from oyster shell) equiv.  to elemental calcium 200mg)

        10 Cap

East African (R)

ALFARIV-C

(Alfacalcidol 0.2mcg, 1250mg Calcium Carbonate 200mg)

        10 Caps

Clanthis Life Sciences

ALFAROL-D3

(Alfacalcidol 0.25rncg (1a-Hydroxyvitsmin D3), Elemental Calcium 500mg)

        10 Tabs

Orchid

ALFASET

        10 Caps            0.25 mg

Welkin Boon

ALFASHELL

(Atfacalcidol 0.25mg, Calcium Carbonate 200mg)

        10 Tabs

Pure Health

ALFASURECAL

(Alfacalcidol 0.25mcg, (1 alpha-Hydroxy Vitamin D-3), Calcium Carbonate equiv. to Elemental Calcium 200mg)

        10 Caps

Alpha Drugs & Pharma

ALFA-SYNTHOCAL

(Alfacalcidol 0.25mcg, Calcium Carbonate equiv. to Elemental Calcium 500mg)

        3x10 Tabs

Vintage Labs

ALFAVIT

(Alfacalcidol 0.25mcg, Calcium Carbonate 370mg,NaturalBeta Carotene 15% 10.33mg dispersion (derived from naturally occurring mixed Carotenoids equiv. to Vit A activity 2500i.u.)

        10 Soft gel Cap

Zee Lab

ALFEX

(Alfacalcidol 0.25mcg, Calcium Carbonate 625mg)

        10 Caps

Osper Pharma

ALPHA B-CAL

(Alphacalcidol 0.2smcg, Calcium Carbonate 500mg, Beta Carotene 15% Distersion (Derived From Naturally occurring mixed Carotenoids equiv. to Vit A activity 2500 i.u.) 10.33mg)

        10 Tabs

Bipl (Radico Remedies)

ALPHABID

(Alphacalcidol 0.25mcg, Cacliurn Citrate 1000mg, Anti-oxidant, Vitamin, Minerals, Glutamic Acid)

        10X3 Tabs

 

Finecure

CAD-ALPHA

(Calcium Carbonate (from oyster shell) equiv. to Elemental Calcium, Alphacalcidol 0.25mcg)

        10 Tabs

Cadila Pharma

CALCIROL GRANULES (Cholecalciferol 60,000 i.u.)

        1g Gran

Zydus Biogen

CALCIT

        10 Tab             0.25mcg

Panacea

CALCOM

(Calcitriol 0.25mcg, calcium carbonate (from oyster shell) equiv. to elemental calcium 100mg, dried zinc Sulphate equiv. to lementral zinc 7.5mg)

        10 Caps

Kee Pharma

CALFA PLUS