CETIRIZINE

Mechanism of action

It is a metabolite of hydroxyzine (piperazine derivative) with marked affinity for peripheral H1 receptors. It is well absorbed orally, penetrates brain poorly.

 

It is not metabolized and is excreted unchanged primarily in urine. It does not prolong cardiac action potential or produce arrhythmias when given with erythromycin/ ketoconazole. Action starts in 1-2 hours. It lasts for 12-24 hours.

 

Indications

Urticaria, atopic eczema and contact dermatitis. Acute allergic reactions due to drugs, foods and insect bites. Ocular symptoms like redness, allergic rhinitis, , lacrimation and itching.

 

Dosage Adults

10mg once a day (Max. 20mg/day).

 

Children

Not recommended for children below 6 months of age.  12 to 23 months: 2.5mg once a day.

Dose as per body wt. : 30kg and less : 5mg. once daily. More than 30 kg : 10mg once daily

 

Contraindications

Hypersensitivity.

 

Special Precaution

Renal dysfunction.  Avoid operating machinery or driving.              

 

Adverse Drug Reactions

GI upset with nausea, vomiting, epigastric distress, constipation or diarrhoea. Headache, dizziness, agitation, dry mouth and urinary hesitancy. It causes some amount of sedation

 

Status in

1. Pregnancy  : Use with caution.

2. Lactation     : Contraindicated

3. Old age        : May be used in reduced size.

4. Children      : Not recommended for more than 1year .

 

Interactions

Alcohol: Avoid excessive alcohol consumption.

 


Brands available and preparations of cetirizine DIHYDROCHLORIDE

 

alday                                     Sol                 

10 Tab                  10mg           9.65            N.A

AIDAY                                    BIPL

10 Tab                                   18.50         15.00

ALCE                            Franklin Lab

10 Tab                  10mg         20.00            N.A

ALCET                                Osper

10x20 Tab            10mg            N.A            N.A

ATCET                          A to Z Pharma

10 Tab                  10mg           9.90           8.32

AVIZIN                          Avalanche Pharma

10 Tab                                   24.00         20.16

AZ                                 Sienna Formulation

50 Tab                  10mg         90.00         72.00

ALERBLOC                          KAPL

10 Tab                  10mg         20.00            N.A

60ml Sus.         5mg/5ml         24.50            N.A

ALERID                                  Cipla

10 Tab                  10mg         31.50            N.A

30ml Syr           5mg/5ml         13.75            N.A

ALERTAC                     Seagull Pharma

10 Paed Tab           5mg         10.00            N.A

10 Tab                  10mg         19.80            N.A

60ml Syr           5mg/5ml         24.00            N.A

ALLERZINE                  Jenburkt

10 Tab                  10mg         16.50            N.A

ALZINE                                  Core

10 Tab                  10mg           7.80            N.A

BANCET                       Bantom Lab

20x10 Tab            10mg         25.00         20.50

BIO ACT                         Bio-Drug

10 Tab                  10mg         14.40            N.A

CEFID                            Novamed

10 Tab                  10mg         25.20            N.A

CERIZINE-FT                    Emcure

10 DT                      5mg         19.00            N.A

C-DAY                          Suvik Hitek

10 Tab                  10mg           9.50           7.79

C-TEC                           Perk Pharma

5x4                       10mg         29.00         24.16

CERTEN                        Wens Drugs

10 Tab                  10mg         16.05         13.48

CET-HL                         H.L.Healthcare

10 Tab                  10mg           9.90            N.A

CETAG                         Agron Remedies

10 Tab                  10mg         10.00           8.20

CETARIV                      East African (R)

10 Tab                  10mg         16.00            N.A

60ml Syrup       5mg/5ml         26.00            N.A

CETGEL                        Universal

10 Cap                  10mg         13.75            N.A

CETICAD                      Zydus Cadila

50x10 Tab            10mg     1300.00            N.A

CETIN                             Ind-Swift

10 Tab                  10mg         27.50            N.A

CETINE-DT                   Paradigm H.Care

20x10 Tab            10mg       280.00       238.00

CETIRIZ                              Alkem

10 Tab                  10mg         29.95         24.60

30ml Syr           5mg/5ml         17.25         14.99

CETNAC                       Nac International

7x10 Tab              10mg       109.00         88.92

CITNOR                        Nordic Formulation

10 Tab                  10mg            N.A            N.A

CETON                            Techyon

10 Tab                  10mg         20.00         16.66

CETOZ                          Marc India

10 Tab                  10mg         24.00         20.00

CEPTINE                       Petrosolv Ltd.

30ml Syrup       5mg/5ml         16.00            N.A

CETRACARE MD          Royal Lab

10 Tab                  10mg         22.00         18.48

CETRAMAC                 Torque Pharma

10 Tab                  10mg         15.00            N.A

CETRAL

10 Tab                  10mg         24.50            N.A

CETRIDOC                    Glenmark

10 Tab                  10mg         19.75         15.98

CETRINE                       Dr. Reddy’s Lab

10 Tab                  10mg         15.30         11.46

30ml Syr             1mg/ml         13.05           9.77

CETRINO                      Vindas Chemical

10 Tab                  10mg         21.00            N.A

CETRISH                       Moreish Pharma

10 Tab                  10mg         16.50         13.77

CETRITOP-10               Alde Medi Impex

10 Tab                  10mg         22.00            N.A

CETRIWAL                       Wallace

10 Tab                  10mg         21.00         17.25

CETRIZET                               Sun

10 Tab                    5mg         20.00            N.A

                             10mg         34.00            N.A

CETVIL                         Raymond

10 Tab                  10mg         15.00         12.50

60ml Syrup       5mg/5ml         24.00         20.00

CETZIKAN                    Kansas Lab

10 Tab                  10mg         11.00            N.A

CETRUZET                   Spectra (Sun)

10 Tab                    5mg         16.00            N.A                       10mg       30.00       N.A

CETZINE                                 GSK

10 Captab             10mg         29.95         25.39

60 ml Syr          5mg/5ml         26.48         23.60

CETZY                             Zee Lab

20 Tab                  10mg         32.00         26.60

CEZ                               Finecure Pharma

10 Tab                  10mg         12.50         10.77

CITOL-DT                     Olcare Lab

20 Tab                  10mg         32.00         26.24

60ml Syrup     10mg/5ml         21.90         17.96

CLARITEC                       Wander

10 Tab                  10mg         12.82            N.A

COPE                            Mankind Pharma

10 Tab                  10mg         11.00           8.80

COSZIN                                   CEL

10 Tab                  10mg         24.00            N.A

30ml Syr           5mg/4ml         12.50            N.A

CRAB                            Kwik H.Care

10 Tab                  10mg         24.00         19.68

CYPZINE                       Cyper Pharma

30x10 Tab            10mg       450.00       360.00

CTZ                                          PIL

10 Tab                  10mg         16.00            N.A

CZ-3                                     Lupin

10 Tab                  10mg         27.00         21.65

60 ml Syr          5mg/5ml         27.00         21.65

ECITRA                         Elegant Drugs

10 Tab                  10mg           9.00            N.A

EKON                            Blue Cross

10 DT                      5mg         19.00            N.A

                             10mg         25.00            N.A

30 ml Syr.         5mg/5ml         13.50            N.A

ELTRIZIN                      Lancer H.Care

20x10 Tab            10mg       220.00            N.A

ENCET                           Endocard

10 Tab                  10mg         15.00         12.54

ENOCET                        Zenon H. Care

10 Tab                  10mg         16.00            N.A

EXCET                          Excare Lab

20 Tab                  10mg         32.00         26.24

60ml Syrup     10mg/5ml         21.90         17.96

FLORAMIN                   Bestochem

10 Tab                  10mg         10.00           8.00

FOMICET                              Geno

10 Tab                  10mg         20.00            N.A

FULDAY                             Arvind

10 Tab                  10mg         14.00         11.86

FAZINE                         Faith Pharma

20 PD Tab               5mg         40.00            N.A

20 DT                    10mg         70.00            N.A

GLAG                           Bupa Pharma

10 Tab                  10mg         27.50            N.A

HICET                           Micro Nova

10 Tab                 10 mg         14.80         12.13

30 ml Syr.         5mg/5ml         13.80

HISNOFIL                            Rextar

10 Tab                  10mg         26.50            N.A

HISTANIT                             Signit

10 Tab                  10mg         15.00         12.00

50ml Syrup     10mg/5ml         21.00         17.50

HISTAZIN                            JKDPL

10 Tab                  10mg         27.00            N.A

IFYCET-DT                   Sanify H.Care

10 Tab                  10mg         24.90         20.92

INCEZ-DT                     Intra Labs

30x10 Tab            10mg       600.00            N.A

INCID-L                                Bayer

10 Tab                  10mg         23.00         22.32

JOCET                               Unique

10 Tab                  10mg         21.13            N.A

LIFCET                         Iscon Lifesciences

10 Tab                  10mg         12.00            N.A

LGNIL LS                            LGLSI

30ml Syr.          5mg/5ml         14.00            N.A

M-CET                          Menarini Raunaq

10 Tab                 10 mg         15.00            N.A

30ml Syr.          5mg/5ml         12.23            N.A

METRIZ-10                   Mamta Pharma

10 Tab                  10mg         10.00           8.40

N-ZIN                                  Nestor

10 Tab                  10mg         26.00         22.09

30ml Susp.       5mg/5ml         12.00         10.20

NACET                          Nascent Medicare

10x20                   10mg       250.00       205.00

NBCET                          N.B.Pharma

3x10x10 Tab        10mg       540.00            N.A

NEUSONIL                                PCI

10 Tab                  10mg         26.00         20.80

OCET                            Calyx Medicare

10 Tab                  10mg         16.55         13.79

ODACET                       Mapra Lab

10 Tab                  10mg         15.00         11.22

30ml Syr           5mg/5ml         12.23           9.97

60ml Syr           5mg/5ml         23.15            N.A

OLCET                          Wintech Pharma

10 Tab                  10mg         16.00         12.80

ONCET                          Medley Pharma

10 Tab                 10 mg         10.00            N.A

OSHZIN-10                   Oshin Labs

10 Tab                  10mg         20.00            N.A

PARCET                       Paras Lab

10 Tab                  10mg         18.00         15.00

QUZINE                         Armour Remedies

10 Tab                  10mg         18.00         15.00

RECET                          Reddy Pharma

10 Tab                  10mg         25.20            N.A

30ml Syp                5mg         13.50            N.A

RINITRIN                       Svizera Healthcare

10 Tab                  10mg         13.89         11.38

RHIZIN                                 Recon

10 Tab                    5mg           9.00            N.A

10 DT                    10mg         18.95            N.A

10Tab F               20 mg         29.00            N.A

60 ml Syr          5mg/5ml         23.90            N.A

SETRI                            Swisskem H.Care

10 Tab                  10mg         21.20            N.A

SILPAZINE                          Richie

10 Tab                  10mg         26.50         20.00

50ml Syp.         5mg/5ml         22.50         17.00

SIT-10                           Khushal Pharma

10 Tab                  10mg         18.00         15.03

SIZON                             Systopic

10 Tab                  10mg         29.50            N.A

10 Tab Forte         20mg         44.00            N.A

SIZON-5                          Systopic

10 Tab                    5mg         19.00            N.A

SPAZIN                         Emson Medichem

10 Tab                  10mg         13.00         10.92

SUHIT                           Ramose Lab

10 Tab                  10mg         15.00         12.50

SYTRA                          Synokem

10 Tab                  10mg         20.95         15.90

TAURCET                     Taurus Pharma

10 Tab                  10mg         12.00           9.74

60ml Syr           5mg/5ml         23.80         19.32

TRIZ                                   Indoco

10 Tab                  10mg         17.00         16.39

30ml Syr           5mg/5ml         14.20         13.11

TRICIT                          Shinto Pharma

10 Tab                  10mg            N.A            N.A

TRIZINE                        Apco Pharma

10 Tab                  10mg         21.00         16.80

TROZ-10                         Dynamic

10 Tab                  10mg            N.A            N.A

URTIZINE                      Rachet Biotech

10 Tab                  10mg         19.00         15.83

UNICET                         Bal Pharma

10 Tab                  10mg         24.00

V-CET                              Versatil

10 Tab                  10mg         10.00           8.33

30ml Syrup       5mg/5ml         16.00         13.33

60ml Syp.         5mg/5ml         23.50         19.58

VARCET MD                Zota Healthcare

10 Tab                  10mg         18.00         14.76

ZECET                          Chemo Drugs

10 Tab                  10mg         10.00           8.20

ZETOP                                 Cadila

10 Tab                  10mg         23.92            N.A

Z-CET                              Centaur

10 Tab                  10mg         14.09            N.A

ZIMAT                                 Kresp                 

10 DT                    10mg         20.25            N.A

60ml Syr           5mg/5ml         24.25         19.89

ZIN                                Laborate Pharma

50x10 Tab            10mg       475.00            N.A

ZIRLON                         Waves Bio-tech

10 Tab                  10mg         19.90            N.A

ZIRTIN                              Torrent

10 Tab                  10mg         25.70         21.09

ZOLASE                       Elkidz (Elder)

60ml syrup       5mg/5ml         25.00            N.A

ZOTACET-MD              Zota Pharma

10 Tab                  10mg         16.90         13.86

ZUCET                          Glosun Pharma

10 Tab                  10mg         18.95         15.16

ZIRLON TAB.               Waves Bio-Tech

10 Tab                 10 mg         19.90            N.A

ZYNCET                         Unichem

10 Tab                  10mg         28.50         24.43

60ml Sus          5mg/5ml         26.00         21.29

ZYRTEC                                  UCB

10 Tab                  10mg         25.79            N.A

60ml Syr           5mg/5ml         24.27            N.A