LORATADINE

 

Mechanism of action

It is a piperidine derivative and is a long acting selective peripheral H1 antagonist which lacks CNS depressant effects and is faster acting than astemizole. It is rapidly, absorbed, not metabolised and is excreted unchanged primarily in urine. In contrast to terfenadine and astemizole, it has not produced cardiac arrhythmia in overdose. Action starts in 1-3 hours. It lasts for 24 hours.

 

Indications

Allergic skin disorders specially atopic dermatitis and urticaria. Allergic rhinitis

 

Dosage

Adults

10mg once a day.

 

Children

Less than 2yrs : Not recommended; 2-12 years: 5mg if less than 30kg ; 10mg if more than 30kg

 

Contraindications

Hypersensitivity

 

Special precaution

Caution in patients with renal impairment and elderly.

 

Adverse drug  reactions

Nausea, epigastric distress. Fatigue and light headedness

 

Status in

1. Pregnancy  : Use with extreme caution.

2. Lactation     : Contraindicated

3. Old age        : Use in reduced dose.

4. Children      : Use with extreme caution.

 

Interactions

Cimetidine, ranitidine ,  theophylline, macrolide antibiotics and ketoconazole: Though they inhibit hepatic metabolism of loratadine, no clinically significant interaction is noteded.

 

Brands available and preparations of  loratadine

 

ALASPAN                         Fulford

30ml Syr.            1mg/ml         46.00         37.75

4 Tab                    10mg         60.40            N.A

ALGO                              Rapross

10 Tab                  10mg         28.00            N.A

ALGYFREE                         Galpha

10 Tab                  10mg         23.00         18.85

30ml Syp.         5mg/5ml         18.68         15.31

ALLERBAN                    Saga Lab

30 Tab                  10mg         88.50         72.53

CETSU                          RPG Pharma

10 Tab                  10mg         28.50         23.94

30ml Susp.       5mg/5ml         19.70         16.55

60ml Susp.                             34.66         29.11

LOR-OD                        Swede- India

10 Tab                  10mg         29.40            N.A

LORACT                       Organic Labs

10 Tab                  10mg         32.00            N.A

LORATE                       Pifer Pharma

10 Tab                  10mg         36.00         29.00

LORATIA-10                Chemo Biological

10 Tab                  10mg         28.00         22.96

LORDAY                       MDC Pharma

10 Tab                  10mg         38.00         31.60

LORFAST                       Le Sante

10 Meltab              10mg         38.07            N.A

LORGIC                        Synmedic Lab

10 Tab                  10mg            N.A            N.A

60ml Susp.       5mg/5ml            N.A            N.A

LORANGE                     Panjon Pharma

10 Tab                  10mg         19.00            N.A

LORHIST                      Hitech Formulation

10 Tab                  10mg            N.A            N.A

LORID                           Finecure Pharma

10 Tab DT             10mg         34.50            N.A

LORIDIN                        Zydus Cadila

10 Rapitab            10mg         38.35         32.60

30ml Sus            1mg/ml         18.90            N.A

LORIN                            Stadmed

10 Tab                 10mg.         28.06         23.00

30ml Syr           5mg/5ml         18.04         14.78

LORINOL                      Micro Labs

10 Tab                  10mg         32.00            N.A

LORKIN                         Welkin Boon

10 Tab                  10mg         39.00         32.75

LORMEG                         Alembic

10 DT                    10mg         23.80            N.A

60ml Syr.          5mg/5ml         19.50            N.A

LOR-10                         Mcneil & Argus

10x10 Tab            10mg            N.A            N.A

LORPD                          Pharma Drug & Che.

10x10 Tab            10mg       365.00       309.32

LORONET                     Klar Sehen

10 DT                    10mg         22.00            N.A

MYLOR                         Radix Biotech

10x10 Tab            10mg            N.A            N.A

NEORATE                     Biocin Genetics &                                       

Pharma

20x10 Tab            10mg       530.00       434.60

OLANG-DT                   Olcare Lab

20 Tab DT               5mg         32.50         26.65

                             10mg         55.80         45.75

ORID                                Dynamic

10 Tab                  10mg            N.A            N.A

PRODIN                         Mefro Pharma

10 Tab                  10mg         37.50         30.80

ROLETRA                           Rexcel

10 Tab                  10mg         28.00         22.99

30ml Sus            1mg/ml         20.00         16.42

SNIZID                                 Profic

10 Tab                  10mg         22.00         18.03

SVLORAT                    Taurus Labs

10 Tab                  10mg         34.44         29.80

TADI                             Quixotic Pharma

10x10 Tab            10mg       325.00       273.00

30ml Susp.       5mg/5ml         18.00         15.12

TAROL                         Mentis Pharma

10x10 Tab            10mg       300.00       241.21

TIRLOR                           Novartis

10 Tab                  10mg         19.50         15.75

ZELET-10                        Zee Lab

10 Tab                  10mg         50.00         41.00

Brands available and combination preparations of

Loratadine

COLBID                        Panjon Pharma

(Loratadine 5mg, Pseudoephedrine Hcl 120mg)

10 Tab                                   29.00            N.A

LORACT-D                   Organics Labs

(Loratadine 5mg, Pseudoephedrine Hcl 120mg)

10 Tab                                   29.50            N.A

LORFAST-AM               Le Sante

(Loratadine 5mg, Ambroxol 60mg)

10 Tab                                   30.00            N.A

LORID-D                       Finecure Pharma

(Loratadine 5mg, Pseudoephedrine Hcl 120mg)

10 Tab                                   34.50            N.A

LORIDIN-D                    Zydus Vaccicare

LORIDIN-D                    Zydus Vaccicare

(Loratadine 5mg, Pseudoephedrine Hcl 120mg)

10 Tab                                   20.22         17.32

NEORATE-D                  Biocin Genetics &

                                         Pharma

(Loratadine 10mg, Pseudoephedrine Hcl 60mg)

20x10 Tab                           560.00       459.20

PRODIN-D                     Mefro Pharma

(Loratadine 10mg, Pseudoephedrine)

10 Tab                                   39.50         32.40

SNIZID PLUS                Profic Organic

(Loratadine 5mg, Phenylpropanolamine Hcl 25mg, Paracetamol 500mg)

10 Tab                                   20.00         16.39